Potassium Carbonate → HCID 57150075, compound

Participants

Reaction Steps

To 5 ml of a DMF solution containing 250 mg (0.6477 mmol) of 2,2'-dihydroxy-5,5'-bis(3-methoxycarbonylpropyl) biphenyl and 0.920 ml (6.477 mmol) of cyclohexylmethyl bromide, there was added 360 ml (2.5907 mmol) of anhydrous potassium carbonate and a small amount of copper powder and the resulting mixture was agitated overnight at 100° C. The reaction mixture was filtered by suction through Celite to remove the solid matter, which was washed with ethyl acetate. After the solvent in the filtrate had been evaporated off under reduced pressure, the evaporated residue was dissolved in chloroform. This solution was washed with dilute hydrochloric acid, dilute aqueous sodium bicarbonate, water and saline solution in this sequence and was dried over anhydrous sodium sulfate. The residue obtained after the solvent had been evaporated off was purified by silica gel column chromatography (with 12 g of WAKO-gel C-200, eluent: hexane and hexane/ethyl acetate of 25/1) to obtain 224 mg (0.3877 mmol, 60%) of 2,2'-dicyclohexylmethoxy-5,5'-bis(3-methoxycarbonylpropyl) biphenyl as a white solid.

Provenance & Evidence