HuagongsheHuagongshe Chemistry Print Report · For research reference only
1-Methoxy-2-propanol → 2',6'-Dimethyl-N-(2-Methoxy-1-Methylethoxymethyl) 2-Chloroacetanilide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1-Methoxy-2-propanol | HCID 7900 | — |
| Reactant | 2-Chloro-N-(chloromethyl)-N-(2,6-dimethylphenyl)acetamide | HCID 13069882 | — |
| Solvent | 1,2-Dichloroethane | HCID 11 | — |
| Product | 2',6'-Dimethyl-N-(2-Methoxy-1-Methylethoxymethyl) 2-Chloroacetanilide | HCID 53804968 | 99.1% |
Reaction Steps
About 12.3 g (0.050 mole) of 2',6'-dimethyl-N-(chloromethyl) 2-chloroacetanilide dissolved in twenty (20) ml of ethylene dichloride was added to 22.5 g (0.25 mole) of 2-methoxy-1-methyl ethanol. The solution was allowed to stand one hour at room temperature. Excess alcohol and HCl was removed under vacuum on a rotary evaporator. The residual oil was treated with an additional 22.5 g fresh alcohol for 30 minutes at 60° C. Excess alcohol and HCl was removed as before at 65° C./1 mm Hg. The light yellow oily residue weighed 14.86 g (99.1% yield). Refractive index of the oil, n26D 1.5263. Proton NMR was consistent with structure.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05155272 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-0eb9537c996a4f38abfb6431391683cf |
| Source note | uspto-grants-1992_10 |