反应详情

温度

80 °C

A mixture of 2.13 g (10 mmol) of N-(4-acetylphenyl)methanesulfonamide, 1.78 g (10 mmol) of N-bromosuccinimide and 0.28 g of dibenzoyl peroxide in 100 ml of carbon tetrachloride is heated for 16 hrs at 80° C. (oil bath). The resulting product is concentrated and extracted with methylene chloride. The extract is deposited on silica gel and chromatographed with 1% methanol-methylene chloride to give a product which is recrystallized from methylene chloride-pet. ether; m.p. 124°-126° C. MW 292.17.

1. concentrationThe resulting product is concentrated
2. extractionextracted with methylene chloride
3. customchromatographed with 1% methanol-methylene chloride
4. customto give a product which
5. customis recrystallized from methylene chloride-pet. ether