N-(2-acetylphenyl)methanesulfonamide → N-[3-(2-bromoacetyl)phenyl]methanesulfonamide

HRID 466354Notes

Reaction equation

HRID 466354 reaction equation
[Br:1][CH2:2][C:3](C1C=CC=CC=1NS(C)(=O)=O)=[O:4].C([C:19]1[CH:29]=[CH:28][CH:27]=[CH:26][C:20]=1[NH:21][S:22]([CH3:25])(=[O:24])=[O:23])(=O)C>>[Br:1][CH2:2][C:3]([C:27]1[CH:26]=[C:20]([CH:19]=[CH:29][CH:28]=1)[NH:21][S:22]([CH3:25])(=[O:23])=[O:24])=[O:4]

Participants

3

Reactant 2

HCID 2767200N-(2-acetylphenyl)methanesulfonamideHCID 18380501N-[2-(bromoacetyl)phenyl]methanesulfonamide

Product 1

HCID 11346858N-[3-(2-bromoacetyl)phenyl]methanesulfonamide

Procedure

2'-(Bromoacetyl)methanesulfonanilide can be derived from 2'-acetylmethanesulfonanilide (Preparation 1) following the bromination procedure described in Example 10, Step X. In a like manner, 3'-(2-bromoacetyl)methanesulfonanilide can be obtained.

Sources & evidence

ORD record
ord-9e2c611cbc954bcdaf34ccf17ca38a53
Source dataset
uspto-grants-1992_10
Patent number
US05155268

Reaction notes

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