反应详情

To 38.43 grams (0.10 mole) of 1-diphenylmethyl-2-methyl-2-thiopseudourea hydroiodide in 200 milliliters of o-dichlorobenzene was added 10.22 grams (0.10 mole) of N,N'-dimethyl-1,3-propanediamine and the resulting mixture heated under reflux for 21 hours. The reaction mixture was cooled, the solvent decanted therefrom and isopropanol added to the gummy residue to obtain 24.35 grams (59.8 percent yield) of 2-diphenylmethylimino-1,2,3,4,5,6-hexahydro-1,3-dimethylpyrimidine hydroiodide product of m.p. 215°-219° C. After two recrystallizations from methanol-isopropanol, a purified product, m.p. 221° C., was obtained.

1. temperaturethe resulting mixture heated
2. temperatureunder reflux for 21 hours
3. temperatureThe reaction mixture was cooled
4. customthe solvent decanted
5. additionisopropanol added to the gummy residue