反应详情

A mixture of concentrated sulphuric acid (190 ml) and water (190 ml) was added dropwise to a stirred solution of compound 18 (19.0 g, 0.098 mol) in glacial acetic acid (380 ml). The stirred mixture was heated under reflux for 48 h, cooled in a refrigerator for 24 h and the product was filtered off and dried (CaCl2) in vacuo to give pale-yellow crystals.

1. temperatureThe stirred mixture was heated
2. temperatureunder reflux for 48 h
3. temperaturecooled in a refrigerator for 24 h
4. filtrationthe product was filtered off
5. dry with materialdried (CaCl2) in vacuo
6. customto give pale-yellow crystals