Nicotinic Acid → HCID 178512931, compound

Participants

Reaction Steps

307.5g (2.5 mol) of nicotinic acid in 400 ml aqueous methanol are added to a suspension of 435 g (2.5 mol) of arginine base in 400 ml water. The resulting mixture is heated for one hour to form a solution which is concentrated in vacuo. The resulting yellow, oil residue is recrystallized from 1.5 l ethylacetate. The crystals are collected and then resuspended in diethylether. Thereafter, the crystals are recollected, washed with diethylether and dried in vacuo at 50 degrees C. Consequently, 450 g (61%) of arginine nicotinate are derived, having a melting point of between 163°-166 degrees C.

Provenance & Evidence