Diethyl isobutylmalonate → 2-Isobutyl-2-hydroxymethylpropan-1,3-diol

HRID 466518Notes

Reaction equation

HRID 466518 reaction equation
[CH:1]1([CH:7]([C:13]([O:15]CC)=O)[C:8]([O:10]CC)=O)[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C(C(C(OCC)=O)[C:23](OCC)=[O:24])C(C)C.[CH3:33][C:34](C)([CH3:43])[CH2:35][C:36]([CH2:41][OH:42])([CH2:39][OH:40])[CH2:37][OH:38]>>[CH:1]1([C:7]([CH2:8][OH:10])([CH2:13][OH:15])[CH2:23][OH:24])[CH2:2][CH2:3][CH2:4][CH2:5][CH2:6]1.[CH2:35]([C:36]([CH2:37][OH:38])([CH2:39][OH:40])[CH2:41][OH:42])[CH:34]([CH3:43])[CH3:33]

Participants

5

Reactant 3

HCID 25047Diethyl isobutylmalonateHCID 240541Diethyl 2-cyclohexylmalonateHCID 18953343HCID 18953343, compound

Product 2

HCID 129305352-Isobutyl-2-hydroxymethylpropan-1,3-diolHCID 129305402-Cyclohexyl-2-hydroxymethylpropan-1,3-diol

Procedure

2-Cyclohexyl-2-hydroxymethylpropan-1,3-diol and 2-isobutyl-2-hydroxymethylpropan-1,3-diol were prepared from diethyl cyclohexylmalonate and diethyl i-butylmalonate respectively in a manner analogous to the synthesis of 2-(2,2-dimethylpropyl)-2-hydroxymethyl-propane-1,3-diol (example 5).

Sources & evidence

ORD record
ord-1c072712e11949f0926c8a40dc3c6883
Source dataset
uspto-grants-1992_10
Patent number
US05157029

Reaction notes

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