反应详情

Diethyl 2-benzyloxymethyl-2-(2,2-dimethylpropyl)malonate (15 g.) in dry diethyl ether (50 ml.) was added slowly to a stirred suspension of lithium aluminium hydride (7.0 g.) in dry diethyl ether (200 ml.) at 0°, under nitrogen. The mixture was stirred at room temperature for 12 hours. Aqueous sodium hydroxide solution (25 ml., 10% solution) was added carefully. The mixture was filtered and the solid was washed with diethyl ether. The filtrates were dried over anhydrous magnesium sulphate and evaporated in vacuo. The residue was purified by chromatography on silica, eluting with 1:4 ethyl acetate:hexane. 2-Benzyloxymethyl-2-(2,2-dimethylpropyl)-propan-1,3-diol was obtained as a colorless oil (5.5 g).

1. filtrationThe mixture was filtered
2. washthe solid was washed with diethyl ether
3. dry with materialThe filtrates were dried over anhydrous magnesium sulphate
4. customevaporated in vacuo
5. customThe residue was purified by chromatography on silica
6. washeluting with 1:4 ethyl acetate