HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 466560Generated: October 29, 2026
1-(3-(Trifluoromethyl)phenyl)piperazine → 3-Iodo-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine
https://huagongshe.com/reaction/466560
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 1-(3-(Trifluoromethyl)phenyl)piperazine | HCID 4296 | — |
| Reactant | Sodium Carbonate | HCID 10340 | — |
| Reactant | 3,6-Diiodopyridazine | HCID 250383 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 3-Iodo-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine | HCID 15124595 | 48% |
Reaction Steps
A mixture of 5.2 parts of 3,6-diiodopyridazine, 3.5 parts of 1-[3-(trifluoromethyl)phenyl]piperazine, 3.2 parts of sodium carbonate and 90 parts of N,N-dimethylacetamide was stirred and heated overnight at 70° C. The reaction mixture was poured onto water. The precipitated product was filtered off and crystallized from 2-propanol, yielding 3.2 parts (48%) of 3-iodo-6-[4-[3-(trifluoromethyl)phenyl]-1-piperazinyl]pyridazine; mp. 144.6° C. (compound 202).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US05157035 |
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| Source dataset | uspto-grants-1992_10 |
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| ORD ID | ord-d5ddfdaee6ea4119bfb5e0a1de499f01 |
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| Source note | uspto-grants-1992_10 |
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