Sodium Methoxide → HCID 19814309, compound

Participants

Reaction Conditions

Reaction Steps

A solution containing 34.8 g of 1-benzyl-4-benzylcarbamoyloxy-4-ethynylpiperidine and 1.1 g of sodium methoxide in 350 ml of anhydrous methanol is refluxed for 4 hours. After cooling down and maintaining the reaction mixture at 0° C. for 30 to 60 minutes the crystalline precipitate is filtered and recrystallized from methanol to obtain the title compound in 83% yield, m.p.: 113°-114° C.

Provenance & Evidence