HCID 19814341, compound → HCID 19814236, compound

Participants

Reaction Steps

A solution containing 14.0 g of 8-benzyl-4-hydroxy-4-methyl-2-oxo-1-oxa-3,8-diazaspiro[4,5]decane in 210 ml of dioxane is boiled under nitrogen while azeotropically distilling out the water formed in the reaction. After termination of the reaction dioxane is evaporated under reduced pressure. The residue is recrystallized from ethanol under clarifying by activated carbon to give the title compound in 62% yield, m.p.: 169°-170° C.

Provenance & Evidence