HCID 19814286, compound → HCID 19814358, compound

Participants

Reaction Steps

After refluxing a solution containing 9.6 g of 8-benzyl-4-hydroxy-4-methyl-2-oxo-3-propyl-1-oxa-3,8-diazaspiro[4,5]decane in a mixture of 96 ml of acetic acid and 5.7 ml of acetic anhydride under argon for 5 hours the solvent is evaporated under reduced pressure. After adding 5% by weight aqueous sodium hydroxide solution to the residue up to a pH value of 10, the mixture is extracted with benzene and the organic phase is washed to neutral with water. After drying the organic phase over anhydrous sodium sulfate benzene is evaporated under reduced pressure. After recrystallizing the residue from diisopropyl ether the title compound is obtained in 86.4% yield, m.p.: 70°-71° C.

Provenance & Evidence