HuagongsheHuagongshe Chemistry Print Report · For research reference only
p-Toluenesulfonic acid → HCID 19012216, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | p-Toluenesulfonic acid | HCID 6101 | — |
| Reactant | 4,5-Pyrimidinediamine, 6-chloro- | HCID 78010 | — |
| Reactant | Trimethyl orthovalerate | HCID 83755 | — |
| Solvent | 2-Methoxyethanol | HCID 8019 | — |
| Product | HCID 19012216 | HCID 19012216 | 26.8% |
Reaction Steps
A mixture of 6-Chloro-4,5-diaminopyrimidine (0.289 g, 2 mmol) (from Step 1 of Example 12), trimethylorthovalerate (0.52 ml, 3 mmol) and p-TsOH (0.04 g) in 2-methoxyethanol (10 ml) was refluxed for 24 hours. The product was isolated and purified as described in Step 2 of Example 12 to give the crystalline titled compound (0.113 g, 23%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05157026 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-83f2c3f146214e8aa69270c312eac61a |
| Source note | uspto-grants-1992_10 |