関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Propionic Acid | HCID 1032 | — |
| 反応物 | 4-Methylpyridine-2,3-diamine | HCID 317495 | — |
| 生成物 | 2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 18693036 | 90.6% |
反応手順
A mixture of propionic acid (0.89 ml, 12 mmols), 2,3-diamino-4-picoline (1.23 g, 10 mmol) and polyphosphoric acid (40 g) was heated to 100° C. for 6 hours. Work-up of the reaction and purification of the crude product according to the procedure described in Step 1 of Example 9 gave the desired compound (1.46 g, 90%) as a tan colored solid.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US05157026 |
|---|
| 出典データセット | uspto-grants-1992_10 |
|---|
| ORD ID | ord-36c648157a574f4e940fc5cd20b849e4 |
|---|
| 出典メモ | uspto-grants-1992_10 |
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