Isobutyric Acid → HCID 19012221, compound

HRID 466696Notes

Reaction equation

HRID 466696 reaction equation
[NH2:1][C:2]1[C:7]([NH2:8])=[C:6]([CH3:9])[CH:5]=[CH:4][N:3]=1.[C:10](O)(=O)[CH:11]([CH3:13])[CH3:12]>>[CH:11]([C:13]1[NH:8][C:7]2[C:2]([N:1]=1)=[N:3][CH:4]=[CH:5][C:6]=2[CH3:9])([CH3:12])[CH3:10]

Participants

3

Reactant 2

HCID 6590Isobutyric AcidHCID 3174954-Methylpyridine-2,3-diamine

Product 1

HCID 19012221HCID 19012221, compound

Procedure

The title compound was prepared from 2,3-diamino-4-picoline (0.246 g, 2 mmol) and isobutyric acid (0.19 ml, 2 mmol) according to the procedure described in Step 1 of Example 9. The crude product was purified by flash chromatography on silica-gel using EtOAc-MeOH (20:1) to give the pure product (0.25 g, 72%) as a tan colored solid.

Workup

  1. customThe crude product was purified by flash chromatography on silica-gel

Sources & evidence

ORD record
ord-a52347c586664b13b85c020d2ad8f09f
Source dataset
uspto-grants-1992_10
Patent number
US05157026

Reaction notes

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