HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 466713Erstellt: 25. Oktober 2026
Ammonium Hydroxide → 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine
https://huagongshe.com/reaction/466713
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Ammonium Hydroxide | HCID 14923 | — |
| Edukt | Phosphorus oxychloride | HCID 24813 | — |
| Edukt | HCID 178437532 | HCID 178437532 | — |
| Lösungsmittel | Chloroform | HCID 6212 | — |
| Produkt | 5-chloro-2-ethyl-7-methyl-3H-Imidazo[4,5-b]pyridine | HCID 19385734 | — |
Reaktionsschritte
A mixture of the N-oxide (29.75 g, 0.168 mol), CHCl3 (25 mL) and POCl3 (160 mL) was heated to 80° C. for 1 hours. After pouring over ice, the mixture was neutralized by careful addition of NH4OH and extracted with EtOAc. Concentration gave 23.8 g of 5-chloro-2-ethyl-7-methylimidazo[4,5-b]pyridine as a solid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US05157026 |
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| Quelldatensatz | uspto-grants-1992_10 |
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| ORD ID | ord-8064d2a62fa4477887173a559f968371 |
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| Quellennotiz | uspto-grants-1992_10 |
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