HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 178437441, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | Morpholine | HCID 8083 | — |
| Reactant | Sodium hydride | HCID 24758 | — |
| Reactant | HCID 178468763 | HCID 178468763 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178437441 | HCID 178437441 | — |
Reaction Steps
To 5-(ethoxycarbonyl)-2-ethyl-7-methyl-3-(2'-(tetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine (30 mg) in THF (1 mL) at RT was added 0.25 mL of morpholine and NaH (20 mg of an 80% dispersion). After stirring for 16 hours, 1% aqueous HOAc (2 mL) was added. Extractive workup (EtOAc), and purification (SiO2, 75/25/1 CH2Cl2 /MeOH/NH4OH) gave 10 mg of a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05157026 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-000527745eb44cdc9c693bd0394d1784 |
| Source note | uspto-grants-1992_10 |