Tetrahydrofuran → HCID 178437418, compound

Participants

Reaction Steps

To 5-bromo-2-ethyl-7-methyl-3-(2'-(tetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo-[4,5-b]pyridine (75 mg) in THF (2 mL) at -78° C. was sequentially added ZnCl2 (1.58 mL, 1M/ether), iso-propylmagnesium chloride (0.79 mL, 2M/ether), and tetrakis-triphenylphosphinepalladium (15 mg). After complete addition the reaction was warmed to RT and stirred for 16 hours. Extractive workup (EtOAc, from dilute HOAc), and purification (SiO2, 80/20/1 CH2Cl2 /MeOH/NH4OH) gave 43 mg of a solid.

Provenance & Evidence