HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetyl chloride → HCID 178437452, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetyl chloride | HCID 6367 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | HCID 178437453 | HCID 178437453 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 178437452 | HCID 178437452 | — |
Reaction Steps
To 5-(2-aminoethyl)amino-2-ethyl-7-methyl-3-(2'-(tetrazol-5-yl)biphen-4-yl)methyl-3H-imidazo[4,5-b]pyridine (20 mg) in THF (1 mL) at °C. was added AcCl (3.4 μL) and triethylamine (18 μL). After 1 h, the solvent was evaporated and the residue was purified (SiO2, 80:20:1 CHCl3, MeOH, NH4OH) to give 17 mg of the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05157026 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-4a345daa0b39422885912b0e9c1f71fc |
| Source note | uspto-grants-1992_10 |