Sodium Methoxide → HCID 10445008, compound

HRID 466735Notes

Reaction equation

HRID 466735 reaction equation
[F:1][C@@H:2]1[C@@H:6]([CH2:7][O:8]C(C2C=CC(C)=CC=2)=O)[O:5][C@@H:4]([N:18]2[CH:25]=[C:24]([C:26]#[C:27][Si](C)(C)C)[C:22](=[O:23])[NH:21][C:19]2=[O:20])[CH2:3]1.C[O-].[Na+]>CO>[C:26]([C:24]1[C:22](=[O:23])[NH:21][C:19](=[O:20])[N:18]([CH:25]=1)[C@@H:4]1[O:5][C@H:6]([CH2:7][OH:8])[C@@H:2]([F:1])[CH2:3]1)#[CH:27]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 53678606HCID 53678606, compound

Product 1

HCID 10445008HCID 10445008, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

The product of Stage c), (0.53 g, 1.18 mmoles) was dissolved in methanol (17 ml) containing sodium methoxide (from 0.027 g, 1.18 mmoles of sodium metal) and the solution left standing at ambient temperature for 7 hours. The mixture was then neutralised with Dowex 50 (H+) resin, filtered and evaporated to dryness. The final residue was triturated with ether (2×7 ml) and recrystallised from ethanol to give the title compound.

Workup

  1. waitthe solution left
  2. filtrationfiltered
  3. customevaporated to dryness
  4. customThe final residue was triturated with ether (2×7 ml)
  5. customrecrystallised from ethanol

Sources & evidence

ORD record
ord-01bcbecb38764a719ff412a29fee11e6
Source dataset
uspto-grants-1992_10
Patent number
US05157114

Reaction notes

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