反应详情

温度

50 °C

52.0 g of ethyl (N-methylsulfonyl-N-methylamino)sulfonylcarbamate are dissolved in 500 ml of chlorobenzene, 27.8 g of 2-amino-4-methoxy-6-methylpyrimidine are added at room temperature, and the mixture is heated at 50° C. for 5 hours. After cooling to 0° C., the precipitate is filtered off. After washing with 100 ml of chlorobenzene, 68.8 g of the desired product of a purity of 98.9% are obtained; this corresponds to a yield of 96.4% of theory. The melting point of the product is 118°-120° C.

1. temperatureAfter cooling to 0° C.
2. filtrationthe precipitate is filtered off
3. washAfter washing with 100 ml of chlorobenzene, 68.8 g of the desired product of a purity of 98.9%
4. customare obtained
5. customis 118°-120° C.