HuagongsheHuagongshe Chemistry Print Report · For research reference only
Chloromethyl pivalate → Ticlopidine Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Chloromethyl pivalate | HCID 87885 | — |
| Reactant | N-((2-chlorophenyl)methyl)thiophene-3-ethylamine | HCID 6454012 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | Ticlopidine Hydrochloride | HCID 65335 | 51% |
Reaction Steps
66.5 g (0.44 M) chloromethyl pivalate is reacted by heating, for 3 hours, with a solution of 103 g (0.4 M) N-(2-chloro-benzyl)-2-(2-thienyl)ethylamine in 300 ml dimethylsulfoxide, to give the title compound in a yield of 51%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04174448 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-e1e3cd2e741d47f5826cb8f92d901749 |
| Source note | uspto-grants-1979_11 |