HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyanogen Bromide → 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyanogen Bromide | HCID 10476 | — |
| Reactant | 1-[4-(Diethylamino)-2-butynyl]-1,3-dihydro-3-methyl-2H-imidazol-2-one | HCID 15065532 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one | HCID 15065546 | — |
Reaction Steps
Cyanogen bromide (6.0 g, 0.057 mol) was added to a stirred solution of 1-[4-(diethylamino)-2-butynyl]-1,3-dihydro-3-methyl-2H-imidazol-2-one in dioxane (130 mL). After evaporation of the dioxane, the residual oil was chromatographed on silica gel using chloroform: 1% methanol as the eluant to give 10.8 g of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05157124 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-62fed6f1826f473d8637b3a2f0e51fc7 |
| Source note | uspto-grants-1992_10 |