HuagongsheHuagongshe Chemistry Print Report · For research reference only
Imidazole → 1,3-Dihydro-1-[4-(1H-imidazol-1-yl)-2-butynyl]-3-methyl-2H-imidazol-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Imidazole | HCID 795 | — |
| Reactant | 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one | HCID 15065546 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1,3-Dihydro-1-[4-(1H-imidazol-1-yl)-2-butynyl]-3-methyl-2H-imidazol-2-one | HCID 15065579 | 79.3% |
Reaction Steps
Imidazole (3.87 g, 0.057 mol) was added to a stirred solution of 1-(4-bromo-2-butynyl)-1,3-dihydro-3-methyl-2H-imidazol-2-one (3.26 g, 0.014 mol) in dioxane (50 mL). After 18 hr the dioxane was evaporated and the residue was chromatographed on silica gel to give 2.4 g of product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05157124 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-2c2443c4e5134c559ec7248209210d08 |
| Source note | uspto-grants-1992_10 |