4-Bromobenzyl bromide → Ethyl 2-(4-bromobenzyl)-3-oxohexanoate

HRID 466820Notes

Reaction equation

HRID 466820 reaction equation
[O:1]=[C:2]([CH2:9][CH2:10][CH2:11]CC)[CH2:3][C:4]([O:6][CH2:7][CH3:8])=[O:5].[Br:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19]Br)=[CH:17][CH:16]=1.BrCC1C=CC(C2C=CC=CC=2C2N=NN(C(C3C=CC=CC=3)(C3C=CC=CC=3)C3C=CC=CC=3)N=2)=CC=1>>[Br:14][C:15]1[CH:22]=[CH:21][C:18]([CH2:19][CH:3]([C:2](=[O:1])[CH2:9][CH2:10][CH3:11])[C:4]([O:6][CH2:7][CH3:8])=[O:5])=[CH:17][CH:16]=1

Participants

4

Reactant 3

HCID 685274-Bromobenzyl bromideHCID 4593087Ethyl 3-oxooctanoateHCID 108646215-(4'-(Bromomethyl)-1,1'-biphenyl-2-yl)-2-triphenylmethyl-2H-tetrazole

Product 1

HCID 19814439Ethyl 2-(4-bromobenzyl)-3-oxohexanoate

Procedure

Substituting ethyl butyrylacetate for ethyl 3-oxooctanoate and 4-bromobenzyl bromide for 4-bromomethyl-2'-(2-(triphenylmethyl)tetrazol-5-yl)-biphenyl in Example 4 gave the title compound.

Sources & evidence

ORD record
ord-c0d2f808eb884cefaefe3f7b9337758f
Source dataset
uspto-grants-1992_10
Patent number
US05157040

Reaction notes

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