HCID 11167178, compound → HCID 54028878, compound

Participants

Reaction Conditions

Reaction Steps

Methyl 2,3,6-tri-O-benzyl-α-D-galactopyranoside (5 g, 10.75 mmol) is dissolved at 0° C. in a 9:1 mixture of trifluoroacetic acid and water (50 mL) (N. Morishima, S. Koto, M. Oshima, A. Sugimoto and S. Zen, Bull Chem. Soc. Jpn 56, 2849 (1983)). The mixture is stirred overnight at 0° C. The solvents are evaporated under reduced pressure without heating. The residue is dissolved in ethyl acetate and washed successively with sodium bi-carbonate and brine. The organic layer is dried over sodium sulfate, filtered and concentrated under reduced pressure so as to afford an oil. Flash chromatography on silica gel and elution with a graded mixture of ethyl acetate and hexane will afford 2,3,6-tri-O-benzyl-D-galactopyranose as an oil.

Provenance & Evidence