1,1-Dichloropropene → 1,1-Dichloro-1-iodo-2-trifluoromethylpropane
Reaction equation
CC(C(Cl)(F)F)(C(F)F)[C:3]([F:6])([F:5])[F:4].[Cl:14][C:15]([Cl:18])=[CH:16][CH3:17].FC([I:23])(F)F>>[Cl:14][C:15]([Cl:18])([I:23])[CH:16]([C:3]([F:6])([F:5])[F:4])[CH3:17]Participants
Procedure
CH3C(CF3)(CF2H)CF2Cl (HCFC-3571mps) may be prepared as follows. Commercially available 1,1-dichloropropene may be reacted with commercially available trifluoromethyl iodide to form 1,1-dichloro-1-iodo-2-trifluoromethylpropane which may be dehydrohalogenated to form 1,1-dichloro-2-trifluoromethyl-1-propene. The 1,1-dichloro-2-trifluoromethyl-1-propene may be hydrogenated to form 1,1-dichloro-2-trifluoromethylpropane which may be fluorinated to form l,1-difluoro-2-trifluoromethylpropane. The 1,1-difluoro-2-trifluoromethylpropane may be dehydrogenated to form 1,1-difluoro-2-trifluoromethy-1-propene which may be reacted with commercially available trifluoromethyl iodide to form 1,1-difluoro-1-iodo-2,2-trifluoromethylpropane. The 1,1-difluoro-1-iodo-2,2-trifluoromethylpropane may be chlorinated to form 1-chloro-1,1-difluoro-2,2-trifluoromethylpropane which may be hydrogenated to form 1-chloro-1,1-difluoro-2-difluoromethyl-2-trifluoromethylpropane.
Sources & evidence
- ORD record
- ord-594d5db2033145659bf66ef3dc180220
- Source dataset
- uspto-grants-1992_10
- Patent number
- US05158617
Reaction notes
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