HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Methyl 2-acetylthio-3-(4-methylphenyl)propionate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl 2-bromo-3-(4-methylphenyl)propanoate | HCID 19812946 | — |
| Reactant | Potassium ethanethioate | HCID 23670855 | — |
| Solvent | Water | HCID 962 | — |
| Product | Methyl 2-acetylthio-3-(4-methylphenyl)propionate | HCID 19812945 | 100% |
Reaction Steps
A mixture of methyl 2-bromo-3-(4-methylphenyl)propionate (25.7 g), potassium thioacetate (CH3COSK) (13.7 g) and DMF (120 ml) was stirred for an hour at room temperature. The mixture was poured into water and extracted with ether. The ethereal layer was washed with water, dried (MgSO4) and concentrated to give methyl 2-acetylthio-3-(4-methylphenyl)propionate (25.2 g, 100%) as an oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05158943 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-91ae9cbf435b437daba3612667980f26 |
| Source note | uspto-grants-1992_10 |