Isopropylamine → HCID 19813267, compound

HRID 466979Notes

Reaction equation

HRID 466979 reaction equation
[S:1]1[CH:5]=[CH:4][S:3][C:2]1=[C:6]([C:13]([O:15]C(=O)C(C)(C)C)=O)[C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8].[CH:22]([NH2:25])([CH3:24])[CH3:23]>C(Cl)Cl>[S:3]1[CH:4]=[CH:5][S:1][C:2]1=[C:6]([C:13](=[O:15])[NH:25][CH:22]([CH3:24])[CH3:23])[C:7]([O:9][CH:10]([CH3:11])[CH3:12])=[O:8]

Participants

4

Reactant 2

HCID 6363IsopropylamineHCID 19813258HCID 19813258, compound

Product 1

HCID 19813267HCID 19813267, compoundYield 82.1%

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

A mixture of isopropyl 2-(1,3-dithiol-2-ylidene)-2-(pivaloyloxycarbonyl)acetate (13.2g), isopropylamine (2.6 g) and methylene chloride (60 ml) was stirred at room temperature for 5 hrs. The reaction mixture was washed with aqueous sodium hydroxide solution and water. After removal of solvent the residue was distilled to give the titled compound (9.43 g, 66%) as a yellow oil.

Workup

  1. washThe reaction mixture was washed with aqueous sodium hydroxide solution and water
  2. customAfter removal of solvent the residue
  3. distillationwas distilled

Sources & evidence

ORD record
ord-30802bb3f65e4ee0b3f837493257d88d
Source dataset
uspto-grants-1992_10
Patent number
US05158950

Reaction notes

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