Morpholine → HCID 19813285, compound

HRID 466986Notes

Reaction equation

HRID 466986 reaction equation
[S:1]1[CH:5]=[CH:4][S:3][C:2]1=[C:6]([C:13]([O:15]C(OCC)=O)=O)[C:7]([O:9][CH:10]([CH3:12])[CH3:11])=[O:8].[NH:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1>C(#N)C>[S:3]1[CH:4]=[CH:5][S:1][C:2]1=[C:6]([C:13]([N:21]1[CH2:26][CH2:25][O:24][CH2:23][CH2:22]1)=[O:15])[C:7]([O:9][CH:10]([CH3:11])[CH3:12])=[O:8]

Participants

4

Reactant 2

HCID 8083MorpholineHCID 19813261HCID 19813261, compound

Product 1

HCID 19813285HCID 19813285, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Isopropyl 2-(1,3-dithiol-2-ylidene)-2-(ethoxycarbonyloxy-carbonyl]acetate (20 g) and morpholine (6.23 acetonitrile (200 ml). The mixture was stirred at room temperature for 2 hrs. The reaction mixture was evaporated to dryness and the residue was dissolved inmethylene chloride (100 ml). The solution was washed with aqueous sodium hydroxide solution and water. After evaporation the residue was recyrstallized from ethyl acetate and n-hexane to give the titled compound. (15.0 g, 71.1%)

Workup

  1. customThe reaction mixture was evaporated to dryness
  2. dissolutionthe residue was dissolved inmethylene chloride (100 ml)
  3. washThe solution was washed with aqueous sodium hydroxide solution and water
  4. customAfter evaporation the residue

Sources & evidence

ORD record
ord-234518801e5a4b30b5f27079ae762d91
Source dataset
uspto-grants-1992_10
Patent number
US05158950

Reaction notes

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