1-Piperonylpiperazine → HCID 178419743, compound

Participants

Reaction Steps

A mixture of 2-bromomethyl-2,3-dihydroimidazo[1,2-c]-quinazolin-5(6H)-one (0.5 g, 1.78 mmol), 1-piperonylpiperazine (0.78 g, 3.56 mmol) in acetonitrile (25 mL) was refluxed for 17 hours. The solvent was then removed in vacuo to the oily residue. The residue was purified by column chromatography [silica gel: 25 g, column diameter: 2.5 cm, solvent system: chloroform/ethylacetate (9/1)] to furnish 2-[4-piperonyl-1-piperazinyl]methyl-2,3-dihydroimidazo[1,2-c]-quinazolin-5(6H)-one hydrobromide (620 mg, 67%) and 2-methyl-2,3-dihydroimidazo[1,2-c]quinazolin-5(6H)-one (90 mg, 22%). 2-[4-piperonyl-1-piperazinyl]methyl-2,3-dihydroimidazo[1,2-c]-quinazolin-5(6H)-one hydrobromide: mp 236°-238° C. Anal. Calcd for C23H23N5O3 /H2O/HBr: C, 53.29; H, 5.44; N, 13.50. Found: C, 53.45; H, 5.46 ; N, 13.54.

Provenance & Evidence