HuagongsheHuagongshe Chemistry Print Report · For research reference only
HCID 12811298, compound → 1-Dimethylaminosulfonyl-2-amino-6-(alpha-isopropyl-alpha-hydroxybenzyl)benzimidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | HCID 12811298 | HCID 12811298 | — |
| Reactant | HCID 178418918 | HCID 178418918 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 1-Dimethylaminosulfonyl-2-amino-6-(alpha-isopropyl-alpha-hydroxybenzyl)benzimidazole | HCID 20490458 | 65% |
Reaction Steps
When the procedure of Example 71 was repeated using 4.1 g. (12 mmole) of 1-dimethylaminosulfonyl-2-amino-6-benzoylbenzimidazole in 180 ml. of tetrahydrofuran, 100 ml. tetrahydrofuran, and 28.6 ml. (60 mmole) of isopropyl magnesium chloride in 100 ml. of tetrahydrofuran, there was obtained 1-dimethylaminosulfonyl-2-amino-6-(α-isopropyl-α-hydroxybenzyl)benzimidazole, yield 65%.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04174454 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-718240ed07424b02b0e44cb760447861 |
| Source note | uspto-grants-1979_11 |