HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-4-Nitrophenol → 2-(Chloromethyl)-5-nitro-1,3-benzoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-4-Nitrophenol | HCID 3613389 | — |
| Reactant | Ethyl 2-chloroethanecarboximidate hydrochloride | HCID 12470659 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 2-(Chloromethyl)-5-nitro-1,3-benzoxazole | HCID 2764189 | — |
Reaction Steps
2-Amino-4-nitrophenol (10 g, 65 mmole) and ethyl chloroacetimidate hydrochloride (15.4 g, 97.5 mmole) were heated at reflux temperature in ethanol (100 ml) for 18 hours. The solvent was then removed by evaporation in vacuo and the residue recrystallised from ethanol to give the title compound, yield 9.0 g, m.p. 216°-217°.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05158964 |
| Source dataset | uspto-grants-1992_10 |
| ORD ID | ord-0c7cdef324e84958856a1348304f2bf5 |
| Source note | uspto-grants-1992_10 |