反应详情

To a solution of methyl 4-methyl-2-phenyl-6-(3-nitrophenyl)-1,6-dihydro-5-pyrimidinecarboxylate (475 g) in chloroform (5 l) was added activated manganese dioxide (1.9 kg) and the mixture was refluxed for two hours with stirring vigorously. After allowing to cool to room temperature, manganese dioxide was filtered off. The filtrate was evaporated in vacuo and the residual precipitate was recrystallized from diisopropyl ether (500 ml). The crystal was filtered off, washed with diisopropyl ether and dried in vacuo to give methyl 6-methyl-4-(3-nitrophenyl)-2-phenyl-5-pyrimidinecarboxylate (320 g).

1. temperaturethe mixture was refluxed for two hours
2. filtrationmanganese dioxide was filtered off
3. customThe filtrate was evaporated in vacuo
4. customthe residual precipitate was recrystallized from diisopropyl ether (500 ml)
5. filtrationThe crystal was filtered off
6. washwashed with diisopropyl ether
7. customdried in vacuo