HuagongsheHuagongshe Chemistry Print Report · For research reference only
4-Hydroxybenzaldehyde → 4-(Benzo[d]oxazol-2-yl)phenol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 4-Hydroxybenzaldehyde | HCID 126 | — |
| Reactant | 2-Aminophenol | HCID 5801 | — |
| Solvent | Nitrobenzene | HCID 7416 | — |
| Product | 4-(Benzo[d]oxazol-2-yl)phenol | HCID 2785587 | 64% |
Reaction Steps
Equal molar quantities of p-hydroxybenzaldehyde and o-aminophenol in excess nitrobenzene was refluxed for five hours. The nitrobenzene was removed and the product extracted from the residue with xylene. 2-(4-Hydroxyphenyl)benzoxazole, m.p. 253°, was isolated in 64% yield.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US04174321 |
| Source dataset | uspto-grants-1979_11 |
| ORD ID | ord-97774185b32e4ed8a98473624a78a661 |
| Source note | uspto-grants-1979_11 |