反应详情

To a stirred solution of 4-methyl-5-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione (5.0 g, 2.6×10-2 mole) and 1 molar aqueous NaOH (59 ml, 5.9×10-2 mole) was added a solution of methyl iodide (2.6 ml, 4.2×10-2 mole) and ethanol (13 ml). The reaction was stirred for 3 hours and it was then placed in the refrigerator. After standing in the refrigerator overnight, the precipitate was collected by filtration. Crystallization from isopropanol afforded colorless needles, Mp 134°-135° C.

1. customAfter standing in the refrigerator overnight
2. filtrationthe precipitate was collected by filtration
3. customCrystallization from isopropanol afforded colorless needles, Mp 134°-135° C.