HCID 9950430, compound → HCID 19813412, compound

HRID 467122Notes

Reaction equation

HRID 467122 reaction equation
C([O:4][C:5]([C:7]1[CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[CH:20])[CH:14]=2)[C:11]([C:21]([O:23][CH:24]([CH3:26])[CH3:25])=[O:22])=[C:10]([CH3:27])[NH:9][C:8]=1[CH3:28])=[O:6])(C)C.C(OC(C1C(C2C=CC=C(C#C)C=2)C(C(OCC)=O)=C(C)NC=1C)=O)C>>[C:5]([C:7]1[CH:12]([C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([C:19]#[CH:20])[CH:14]=2)[C:11]([C:21]([O:23][CH:24]([CH3:25])[CH3:26])=[O:22])=[C:10]([CH3:27])[NH:9][C:8]=1[CH3:28])([OH:6])=[O:4]

Participants

3

Reactant 2

HCID 9950430HCID 9950430, compoundHCID 19813392HCID 19813392, compound

Product 1

HCID 19813412HCID 19813412, compoundYield 20.6%

Procedure

The procedure of reaction, treatment and purification of Example 5 were repeated except that 7.6 g (0.02 mol) of 3,5-diisopropoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(3-ethynylphenyl)pyridine obtained in Example was employed instead of 3,5-diethoxycarbonyl-1,4-dihydro-2,6-dimethyl-4-(3-ethynylphenyl)pyridine employed in Example 5 to give 1.4 g of the desired compound (yield: 20%).

Workup

  1. customThe procedure of reaction, treatment and purification of Example 5

Sources & evidence

ORD record
ord-b741e76d364647858b0243fa1edba615
Source dataset
uspto-grants-1992_10
Patent number
US05158963

Reaction notes

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