Trimethylsilyl isocyanate → HCID 54485360, compound

Participants

Reaction Steps

To a solution of N-[5-(3-trifluoromethylphenylthio)thien-2-ylethyl]hydroxylamine (7.6 g) in dioxan (70 ml) at room temperature under nitrogen, was added trimethylsilylisocyanate (5.48 g) and the reaction mixture stirred for 2 hours. The solution was quenched with saturated aqueous ammonium chloride, extracted with ether (2×100 ml), dried over MgSO4, evaporated under reduced pressure to give a yellow oil. The oil was flash chromatographed on a Sorbsil C60-40/60H column using ether to give a white solid, recrystallised from ether-petroleum ether, m.p. 124°-126° C.

Provenance & Evidence