Isothiocyanatotrimethylsilane → HCID 54253279, compound

Participants

Reaction Steps

To a solution of N-[5-n-pentylthiothien-2-ylmethyl]-hydroxylamine (4.36 g) in dioxan (60 ml) at room temperature under nitrogen, was added trimethylsilylisothiocyanate (3.11 g) and the solution heated at reflux for 1 hour. The cooled solution was quenched with saturated aqueous ammonium chloride, dried over MgSO4 and evaporated under reduced pressure to give a brown oil. The oil was flash chromatographed on a Sorbsil C60-40/60H column using ether to give a pale yellow solid, recrystallized from n-hexane to give a cream crystalline solid m.p. 112°-114° C.

Provenance & Evidence