Hydrochloric Acid → HCID 54212794, compound

Participants

Reaction Steps

To a solution of N-[5-(6,6,6-trifluorohexyl)thien-2-ylmethyl]hydroxylamine (1.4 g) in dioxan (50 ml) under nitrogen with stirring, was added trimethylsilyl isocyanate (1.42 ml) and the reaction mixture stirred for 1 hour, poured onto 2N hydrochloric acid (100 ml), extracted with ether (2×100 ml), dried over magnesium sulphate and evaporated under reduced pressure to give a pale yellow oil. The oil was flash chromatographed on a Sorbsil C60-40/60H column using 4:1 hexane/ethyl acetate to give a white solid. Recrystallised from ether/petroleum ether (40°-60° C.) to give a white crystlline solid m.p. 94° C.

Provenance & Evidence