Acetophenone → 7-(alpha-Methylbenzylidenamino)-1-isopropyl-2-methyl-5-trifluoromethylbenzimidazole

Participants

Reaction Steps

Acetophenone (2.8 g.) was reacted with 1-isopropyl-2-methyl-5-trifluoromethyl-7-aminobenzimidazole (4.0 g.) in 50 ml. of xylene for 21 hours according to the procedure of Example 1. After drying over sodium sulfate, the solvent was removed and the crude residue was recrystallized from benzene-cyclohexane (1:1) to give 3.38 g. of the desired product, m.p. 164°-166° C.

Provenance & Evidence