反应详情

A mixture of 2-amino-9-benzyloxy-6-methoxypurine (300mg, 1.11mmol), 10% palladium-on-charcoal (100mg), ethanol (10ml) and dioxan (5ml) was stirred under an atmosphere of hydrogen for 45 minutes. The catalyst was then removed and the filtrate evaporated to a white solid 2-amino-9-hydroxy-6-methoxypurine (190mg, 95%). IR: υmax (KBr) 3312, 1643, 1591, 1394cm-1 ; 1H NMR: δH [(CD3)2SO] 3.95 (3H, s, CH3), 6.45 (2H, br.s, D2O exchangeable, NH2), 7.93 (1H, s, H-8), 11.75 (1H, br.s, OH). Found: m/e 181.0594. C6H7N5O2 requires: m/e 181.0596.

1. customThe catalyst was then removed
2. customthe filtrate evaporated to a white solid 2-amino-9-hydroxy-6-methoxypurine (190mg, 95%)