Chlorosulfonyl isocyanate → HCID 19813655, compound

Participants

Reaction Conditions

Reaction Steps

At 3° C., 3.6 g (0.026 mole) of chlorosulfonyl isocyanate are added to a solution of 6.4 g (0.02 mole) of N-(4-methyl-6-trifluoromethyl-pyrimidin-2-yl)-2-trifluoromethylaniline in 100 ml of ethyl acetate. After stirring the batch for 2 hours at 3° C., 100 ml of ethyl acetate and 50 ml of ice-water are added. The aqueous phase is separated off, and the organic phase is washed with sodium chloride solution, dried with sodium sulfate and concentrated by evaporation in a rotary evaporator. The crystals remaining are triturated with hexane, filtered off and dried in vacuo at 40° C. 6.1 g (83.8%) of the title compound of formula ##STR11## are isolated in the form of crystals having a melting point of 150°-153° C. (Comp. No. 1.020).

Provenance & Evidence