Guanidine → HCID 178455162, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 9.8 g of guanidine free base and 13.8 g of 2-methoxy-3-carboethoxy-5-[t-butyl(dimethyl)silyloxymethyl]-3,4,5,6-tetrahydropyridine was heated at 90° C. under nitrogen for 18 hours. The mixture was cooled to room temperature, and water was added to give a white precipitate. This was filtered to give 9.5 g of the title compound: MS m/z 311 (M+ +1), 310 (M+); 300-MHz 1H NMR (DMSO-d6) δ0.03 (s, 6 H), 0.85 (S, 9 H), 1.70-1.88 (m, 2 H), 2.27-2.38 (m, 1 H), 2.78-2.88 (m, 1 H), 3.16-3.27 (m, 1 H), 3.37-3.45 (m, 1 H), 3.49-3.58 (m, 1 H), 5.92 (b s, 2 H), 6.21 (b s, 1 H), 9.67 (b s, 1 H).

Provenance & Evidence