反应详情

温度

80 °C

To a heated (ca. 60° C.), rapidly stirred mixture of 9.9 grams (0.33 mole) of para-formaldehyde, 4.8 grams (0.12 mole) of finely pulverized, anhydrous sodium hydroxide, and 100 mls. of acetonitrile, was added, drop-wise, 8.4 grams of valeraldehyde. After drop-wise addition of the valeraldehyde had been completed, the reaction mixture was maintained at 80° C. for a period of 1/2 hour. At this time, 8.4 grams of insoluble solid (sodium formate and excess para-formaldehyde) was removed by filtration and discarded. Removal of the actonitrile solvent left 13.3 grams (88%) of a viscous oil which was identified as the title compound, B.P. ca. 140° C.-155° C./0.4 mm Hg.; recrystallized from a chloroform-acetonitrile mixed solvent, m.p. 100°-101° C.

1. temperatureTo a heated
2. customAt this time, 8.4 grams of insoluble solid (sodium formate and excess para-formaldehyde) was removed by filtration
3. customRemoval of the actonitrile solvent
4. waitleft 13.3 grams (88%) of a viscous oil which
5. customrecrystallized from a chloroform-acetonitrile mixed solvent, m.p. 100°-101° C.