Ethyl bromoacetate → HCID 18322352, compound

Participants

Reaction Steps

Among the methods for the preparation of the products of formula (A) above, there is described an O-alkylation that, starting from 2-[(7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)amino]-1-phenylethanol or from 2-[(7-hydroxy-1,2,3,4-tetrahydronaphth-2-yl)amino]-1-(3-chlorophenyl)ethanol, by reaction with ethyl bromoacetate gives the 2-[(7-carbethoxymethoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-1-phenylethanol, hereinafter designated COMPOUND 1, or the 2-[(7-carbethoxymethoxy-1,2,3,4-tetrahydronaphth-2-yl)-amino]-1-(3-chlorophenyl)ethanol, hereinafter designated COMPOUND 2. This reaction does not actually give good results because of the very low yield in final product.

Provenance & Evidence