Dichloromethane → HCID 18648615, compound

Participants

Reaction Steps

A solution of 1 g of (S)-2-[N-(tert-butoxycarbonyl)amino]-7-carbethoxymethoxytetraline, EXAMPLE 5, in 15 ml of methylene chloride is cooled to 0° C. A solution of 2.2 ml of trifluoroacetic acid in 15 ml of methylene chloride is added thereto and the reacting mixture is left under stirring 30 minutes at a temperature of 0°-5° C. and afterwards 4 hours at room temperature. By operating as described in EXAMPLE 4, the (S)-2-amino-7-carbethoxymethoxytetraline hydrochloride is obtained; /alpha/=-52° (methanol, c=1%).

Provenance & Evidence