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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 467327Generated: October 25, 2026

Hydrochloric Acid → Alendronic Acid

https://huagongshe.com/reaction/467327

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantTetramethyl phthalimido-1-hydroxybutylidene-bisphosphonateHCID 9845824—
ProductAlendronic AcidHCID 2088—

Reaction Steps

contacting tetramethyl phthalimido-1-hydroxybutylidene-bisphosphonate from Step (b) with aqueous hydrochloric acid at a temperature range of 80° C. to reflux to form 4-amino-1-hydroxybutylidene-bisphosphonic acid.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS05159108
Source datasetuspto-grants-1992_10
ORD IDord-1ab92b05e0d34afbb421dd2d7859da8f
Source noteuspto-grants-1992_10