Gamma-Aminobutyric Acid → 4-Phthalimidobutyric acid

HRID 467328Notes

Reaction equation

HRID 467328 reaction equation
[NH2:1][CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6].[C:8]1(=O)[O:13][C:11](=[O:12])[C:10]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:9]12>C(O)(=O)C>[C:8]1(=[O:13])[N:1]([CH2:2][CH2:3][CH2:4][C:5]([OH:7])=[O:6])[C:11](=[O:12])[C:10]2=[CH:14][CH:15]=[CH:16][CH:17]=[C:9]12

Participants

4

Reactant 2

HCID 119Gamma-Aminobutyric AcidHCID 6811Phthalic Anhydride

Product 1

HCID 184114-Phthalimidobutyric acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A 2 liter nitrogen flushed flask fitted with a mechanical stirrer and a reflux condenser was charged with 103 g (1 mole) of 4-aminobutyric acid (GABA), 148 g (1 mole) of phthalic anhydride and 250 ml of glacial acetic acid.

Workup

  1. customA 2 liter nitrogen flushed flask fitted with a mechanical stirrer and a reflux condenser

Sources & evidence

ORD record
ord-57e1370364ff48cb8018e72e863c494c
Source dataset
uspto-grants-1992_10
Patent number
US05159108

Reaction notes

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